Performance of two commercial glycoprotein G-based enzyme immunoassays for detecting antibodies to herpes simplex viruses 1 and 2 in children and young adolescents

Clin Diagn Lab Immunol. 2002 Sep;9(5):1124-5. doi: 10.1128/cdli.9.5.1124-1125.2002.

Abstract

In 61 patients 1 to 14 years of age, the Gull/Meridian enzyme-linked immunosorbent assay (ELISA) had a sensitivity of 100% for herpes simplex virus type 1 (HSV-1) and specificities of 74% for HSV-1 and 48% for HSV-2. In 128 similarly aged patients, the HerpeSelect ELISA (Focus Technologies) showed sensitivities of 80% for HSV-1 and 88% for HSV-2, and specificities of 97% for HSV-1 and 100% for HSV-2.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Herpes Simplex / diagnosis*
  • Herpes Simplex / immunology
  • Herpesvirus 1, Human*
  • Herpesvirus 2, Human*
  • Humans
  • Immunoenzyme Techniques*
  • Infant
  • Reagent Kits, Diagnostic
  • Sensitivity and Specificity
  • Viral Envelope Proteins / analysis*
  • Viral Envelope Proteins / immunology

Substances

  • Reagent Kits, Diagnostic
  • Viral Envelope Proteins
  • glycoprotein G, herpes simplex virus type 2