Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives

Süreyya Olgen; Tülay Coban

doi:10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7

Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives

Arch Pharm (Weinheim). 2002 Jul;335(7):331-8. doi: 10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7.

Authors

Süreyya Olgen¹, Tülay Coban

Affiliation

¹ Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Ankara, Tandogan/Ankara, Turkey. [email protected]

PMID: 12207283
DOI: 10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7

Abstract

A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5, 10, 15, 17 are very efficient antioxidants compared to alpha-tocopherol.

MeSH terms

Animals
Antioxidants / chemical synthesis*
Antioxidants / chemistry
Antioxidants / pharmacology
In Vitro Techniques
Indoles / chemical synthesis*
Indoles / chemistry
Indoles / pharmacology
Lipid Peroxidation / drug effects
Liver / drug effects
Liver / metabolism
Molecular Structure
Rats
Superoxides / metabolism
alpha-Tocopherol / pharmacology

Substances

Antioxidants
Indoles
Superoxides
alpha-Tocopherol