Crow-Fukase syndrome associated with high-output heart failure

Intern Med. 2002 Aug;41(8):638-41. doi: 10.2169/internalmedicine.41.638.

Abstract

A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome.

Publication types

  • Case Reports

MeSH terms

  • Cardiac Output, High / diagnosis
  • Cardiac Output, High / etiology*
  • Cardiac Output, High / physiopathology
  • Endothelial Growth Factors / blood
  • Female
  • Heart Failure / diagnosis
  • Heart Failure / etiology*
  • Heart Failure / physiopathology
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood
  • Lymphokines / blood
  • Middle Aged
  • POEMS Syndrome / complications*
  • POEMS Syndrome / diagnosis
  • POEMS Syndrome / physiopathology
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors