Abstract
Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant cancer cells KB-VIN and KB-7d. Compounds and showed significant cytotoxicity in these cell lines. Compounds and also demonstrated significant activity against KB-7d. The biflavonoid isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / pharmacology*
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Cell Survival / drug effects
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Diterpenes / chemistry
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Diterpenes / pharmacology*
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Flavonoids / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Plant Epidermis / chemistry
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Plant Leaves / chemistry
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Taxoids*
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Taxus / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Bridged-Ring Compounds
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Diterpenes
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Flavonoids
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Taxoids
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taxane