Phospholipid scramblase, a new effector of FcepsilonRI signaling in mast cells

Mol Immunol. 2002 Sep;38(16-18):1235-8. doi: 10.1016/s0161-5890(02)00069-x.

Abstract

The signaling network of the high-affinity receptor for IgE in mast cells involves tyrosine phosphorylation of a number of proteins. Here we report evidence that phospholipid scramblase, a protein involved in the distribution of phospholipids between the two leaflets of the plasma membrane, is a target for tyrosine kinases in this signal. The implication of this observation is briefly discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Mast Cells / enzymology*
  • Mast Cells / immunology
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Phospholipid Transfer Proteins*
  • Phosphoproteins / analysis
  • Protein Structure, Tertiary
  • Rats
  • Receptors, IgE / metabolism*
  • Signal Transduction*
  • Tyrosine / metabolism

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Phospholipid Transfer Proteins
  • Phosphoproteins
  • Receptors, IgE
  • Tyrosine