Eruptive multiple lentigo-maligna-like lesions in a patient undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing colorectal carcinoma: a lesson for the pathogenesis of malignant melanoma?

Dermatology. 2002;205(2):174-5. doi: 10.1159/000063905.

Abstract

Induction of multiple eruptive dermal and atypical melanocytic naevi has frequently been reported in children with malignant haematological diseases and chemotherapy-induced immunosuppression. This is the first report of an adult patient to develop multiple eruptive melanocytic skin lesions while undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing cancer. Our observation adds further evidence to the link between systemic (iatrogenic or intrinsic) immunosuppression and the induction of melanocyte proliferation and transformation.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Capecitabine
  • Carcinoma / drug therapy*
  • Carcinoma / secondary*
  • Colorectal Neoplasms / pathology*
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / adverse effects*
  • Deoxycytidine / analogs & derivatives*
  • Drug Eruptions / diagnosis
  • Drug Eruptions / etiology*
  • Drug Eruptions / pathology
  • Fluorouracil
  • Humans
  • Hutchinson's Melanotic Freckle / chemically induced*
  • Hutchinson's Melanotic Freckle / diagnosis
  • Hutchinson's Melanotic Freckle / pathology
  • Male
  • Melanoma / physiopathology
  • Middle Aged
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / pathology
  • Nevus, Pigmented / chemically induced
  • Nevus, Pigmented / diagnosis
  • Nevus, Pigmented / pathology
  • Prodrugs / administration & dosage
  • Prodrugs / adverse effects*
  • Skin / pathology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / physiopathology

Substances

  • Antimetabolites, Antineoplastic
  • Prodrugs
  • Deoxycytidine
  • Capecitabine
  • Fluorouracil