Abstract
We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.
MeSH terms
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Acetamides / pharmacokinetics
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Acetamides / therapeutic use*
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Animals
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / therapeutic use*
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Disease Models, Animal
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Linezolid
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Male
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Methicillin Resistance*
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Mice
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Oxazolidinones / pharmacokinetics
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Oxazolidinones / therapeutic use*
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Respiratory Tract Infections / drug therapy
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Respiratory Tract Infections / microbiology
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Respiratory Tract Infections / mortality
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / mortality
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Staphylococcus aureus / drug effects*
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Teicoplanin / pharmacokinetics
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Teicoplanin / therapeutic use
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Vancomycin / pharmacokinetics
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Vancomycin / therapeutic use*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Teicoplanin
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Vancomycin
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Linezolid