Abstract
In order to accurately analyze gene function in transgenic mice, as well as to generate credible murine models of human diseases, the ability to regulate temporal- and spatial-specific expression of target genes is absolutely critical. Pioneering work in inducible transgenics, begun in the 1980s and continuing to the present, has led to the development of a variety of different inducible systems dedicated to this goal, the shared basis of which is the accurate conditional expression of a given transgene. Recent advances in inducible transgene expression in mice are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents, Hormonal / pharmacology
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Cell Nucleus / metabolism
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DNA, Complementary / metabolism
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Ecdysone / metabolism*
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Ecdysterone / analogs & derivatives
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Ecdysterone / pharmacology
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Gene Transfer Techniques
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Genes, Reporter
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Genetic Techniques*
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Ligands
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Mice
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Mice, Transgenic
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Models, Genetic
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Tamoxifen / pharmacology*
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Tetracycline / pharmacology
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Time Factors
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Hormonal
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DNA, Complementary
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Ligands
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Tamoxifen
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Ecdysone
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Ecdysterone
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ponasterone A
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Tetracycline