Muscle oxygenation and ATP turnover when blood flow is impaired by vascular disease

G J Kemp; N Roberts; W E Bimson; A Bakran; S P Frostick

doi:10.1023/a:1020325812680

Muscle oxygenation and ATP turnover when blood flow is impaired by vascular disease

Mol Biol Rep. 2002;29(1-2):187-91. doi: 10.1023/a:1020325812680.

Authors

G J Kemp¹, N Roberts, W E Bimson, A Bakran, S P Frostick

Affiliation

¹ Department of Musculoskeletal Science, University of Liverpool, UK.

PMID: 12241055
DOI: 10.1023/a:1020325812680

Abstract

31P magnetic resonance spectroscopy (31P MRS) and near-infrared spectroscopy (NIRS) are combined to study interactions between oxidative ATP synthesis rate, perturbation of the creatine kinase equilibrium, and cellular oxygenation state in calf muscle of normal subjects and patients with muscle perfusion impaired by peripheral vascular disease.

MeSH terms

Adenosine Triphosphate / metabolism*
Creatine Kinase / metabolism
Humans
Magnetic Resonance Spectroscopy
Male
Mitochondria, Muscle / metabolism
Muscle, Skeletal / blood supply
Muscle, Skeletal / metabolism*
Oxidative Phosphorylation*
Oxygen / metabolism*
Phosphocreatine / metabolism
Vascular Diseases / metabolism*

Substances

Phosphocreatine
Adenosine Triphosphate
Creatine Kinase
Oxygen