New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2807-10. doi: 10.1016/s0960-894x(02)00624-8.

Abstract

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotin
  • Cell Line
  • Electrophoresis, Polyacrylamide Gel
  • Fatty Acids, Unsaturated / isolation & purification
  • Fatty Acids, Unsaturated / pharmacology
  • HIV Core Protein p24 / biosynthesis
  • HIV Reverse Transcriptase*
  • Humans
  • Iridoids / isolation & purification*
  • Iridoids / pharmacology*
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / isolation & purification*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics
  • Valerian / chemistry*

Substances

  • Fatty Acids, Unsaturated
  • HIV Core Protein p24
  • Iridoids
  • Reverse Transcriptase Inhibitors
  • callystatin A
  • Biotin
  • HIV Reverse Transcriptase
  • valtrate
  • leptomycin B