Pauci-immune extracapillary glomerulonephritis and atheromatous embolization

Am J Kidney Dis. 2002 Oct;40(4):847-51. doi: 10.1053/ajkd.2002.35700.

Abstract

Renal atheroembolic disease presents several multisystemic signs and symptoms that may resemble the clinical signs of vasculitis. A few cases of renal atheroembolism associated with antineutrophil cytoplasmic antibodies (ANCA) have been described. We report the first case, to our knowledge, of a patient with cholesterol microemboli who also developed extracapillary glomerulonephritis in the presence of perinuclear ANCA (p-ANCA) with anti-myeloperoxidase ANCA. The patient had long-term follow-up of renal function after treatment with prednisone and cyclophosphamide.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Antibodies, Antineutrophil Cytoplasmic / metabolism
  • Arteriosclerosis / complications*
  • Arteriosclerosis / drug therapy
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Diagnosis, Differential
  • Embolism, Cholesterol / drug therapy
  • Embolism, Cholesterol / etiology*
  • Glomerulonephritis / blood*
  • Glomerulonephritis / diagnosis
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / immunology
  • Humans
  • Kidney / blood supply
  • Kidney / immunology
  • Male
  • Peroxidase / immunology
  • Renal Artery Obstruction / drug therapy
  • Renal Artery Obstruction / etiology*

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Peroxidase