Metabolic and drug-induced muscle disorders

Curr Opin Neurol. 2002 Oct;15(5):533-8. doi: 10.1097/00019052-200210000-00003.

Abstract

Purpose of review: The inherited disorders of muscle metabolism affect both substrate utilization and the final intramitochondrial oxidation through the Krebs cycle and the respiratory chain. Almost every step of these complex biochemical pathways can be affected by inborn errors, whose expression depends on peculiar tissue-specific or systemic gene expression. This review updates current knowledge in this broad field.

Recent findings: New inherited defects are still being discovered, such as the beta-enolase deficiency in glycogenosis type XIII and mutations in the gene encoding an esterase/lipase/thioesterase protein in Chanarin-Dorfman syndrome, a multisystem triglyceride storage disease.

Summary: Therapeutic approaches to the metabolic myopathies are still lagging behind, although remarkable observations have been made on the rare coenzyme Q10 deficiency syndrome. However, transgenic animal models may offer the opportunity both to investigate muscle pathogenesis and explore therapeutic targets. Finally, human myotoxicity may provide novel paradigms for naturally occurring muscle disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Antioxidants / metabolism
  • Coenzymes
  • Glycogen Storage Disease / metabolism
  • Humans
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / adverse effects*
  • Lipid Metabolism
  • Metabolism, Inborn Errors / metabolism*
  • Mitochondria, Muscle / metabolism
  • Mitochondrial Diseases / metabolism*
  • Muscular Diseases / chemically induced*
  • Muscular Diseases / metabolism*
  • Mutation
  • Phosphopyruvate Hydratase / deficiency
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / deficiency

Substances

  • Antioxidants
  • Coenzymes
  • Hypolipidemic Agents
  • Ubiquinone
  • Phosphopyruvate Hydratase
  • coenzyme Q10