Association of the prtF1 gene (encoding fibronectin-binding protein F1) and the sic gene (encoding the streptococcal inhibitor of complement) with emm types of group A streptococci isolated from Japanese children with pharyngitis

Xiaoming Ma; Hideaki Kikuta; Nobuhisa Ishiguro; Mikio Yoshioka; Takashi Ebihara; Teiko Murai; Intetu Kobayashi; Kunihiko Kobayashi

doi:10.1128/JCM.40.10.3835-3837.2002

Association of the prtF1 gene (encoding fibronectin-binding protein F1) and the sic gene (encoding the streptococcal inhibitor of complement) with emm types of group A streptococci isolated from Japanese children with pharyngitis

J Clin Microbiol. 2002 Oct;40(10):3835-7. doi: 10.1128/JCM.40.10.3835-3837.2002.

Authors

Xiaoming Ma¹, Hideaki Kikuta, Nobuhisa Ishiguro, Mikio Yoshioka, Takashi Ebihara, Teiko Murai, Intetu Kobayashi, Kunihiko Kobayashi

Affiliation

¹ Department of Pediatrics, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, Sapporo 060-8638, Japan.

Abstract

A total of 66 clinical isolates of group A streptococci (GAS) were obtained from 66 Japanese children with pharyngitis. The prtF1 gene (encoding fibronectin-binding protein F1) and the sic gene (encoding the streptococcal inhibitor of complement) were present in 51 (77.3%) and 48 (72.7%) of the 66 isolates, respectively. These results indicated that a high prevalence of two virulence genes, prtF1 and sic, is characteristic of GAS in Japan.

MeSH terms

Adhesins, Bacterial / genetics*
Bacterial Proteins / genetics*
Child
Child, Preschool
Gene Frequency
Humans
Infant
Japan / epidemiology
Pharyngitis / epidemiology
Pharyngitis / microbiology*
Streptococcus pyogenes / genetics*
Streptococcus pyogenes / isolation & purification
Streptococcus pyogenes / pathogenicity
Virulence / genetics

Substances

Adhesins, Bacterial
Bacterial Proteins
SIC protein, Streptococcus
fibronectin-binding proteins, bacterial