Abstract
Three sesquiterpene lactones were isolated from Lourteigia ballotaefolia (H. B. K.). 9beta-hydroxy-atripliciolide-8- O-tiglate ( 1) was isolated for the first time from this plant and was previously reported in Conocliniopsis prasiifolia (DC) K. et R., 9beta-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate) ( 2) had been already reported in this species. The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Asteraceae*
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Croton Oil / pharmacology
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Disease Models, Animal
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Indomethacin / pharmacology
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Inflammation / chemically induced
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Inflammation / drug therapy
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Molecular Structure
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Venezuela
Substances
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9-(tigloyloxy)-atripliciolide
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9-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate)
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9-hydroxy-atripliciolide-8- O-tiglate
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Anti-Inflammatory Agents, Non-Steroidal
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Lactones
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Plant Extracts
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Sesquiterpenes
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Croton Oil
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Indomethacin