Abstract
Five cases of chromosome imbalance resulting from 3:1 disjunction of reciprocal translocations are described. A review of the literature suggests this phenomenon is more common than has previously been recognized.
MeSH terms
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Abnormalities, Multiple / genetics
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Adult
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Age Factors
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Aneuploidy*
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Chromosome Aberrations*
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Chromosomes, Human, 1-3
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Chromosomes, Human, 21-22 and Y
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Chromosomes, Human, 4-5
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Chromosomes, Human, 6-12 and X
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Down Syndrome / genetics
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Female
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Heterozygote
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Humans
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Infant, Newborn
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Intellectual Disability / genetics
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Karyotyping
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Male
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Maternal Age
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Meiosis*
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Pedigree
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Recurrence
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Risk
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Translocation, Genetic*
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Trisomy*