Abstract
This study cloned cDNA of human homologue (hSTAP) of rat stellate cell activation-associated protein (rSTAP). hSTAP gene is on chromosome 17q and is composed of four exons. Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Chromosomes, Human, Pair 17
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Cytoglobin
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DNA, Complementary / biosynthesis
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DNA, Complementary / chemistry
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Exons
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Globins
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Hemeproteins / genetics*
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Hepatitis, Autoimmune / metabolism
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Hepatitis, Viral, Human / metabolism
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Humans
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Immunohistochemistry
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Liver / metabolism*
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Molecular Sequence Data
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Peroxidases / biosynthesis
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Peroxidases / chemistry
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Peroxidases / genetics*
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Recombinant Proteins / chemistry
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Sequence Alignment
Substances
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Cytoglobin
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DNA, Complementary
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Hemeproteins
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Recombinant Proteins
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Globins
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Peroxidases