Abstract
Erythrocyte invasion by Plasmodium falciparum involves multiple ligand-receptor interactions and numerous apparent redundancies. The genome sequence of this parasite reveals new gene families encoding proteins that appear to mediate erythrocyte invasion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Erythrocyte Membrane / parasitology
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Erythrocyte Membrane / ultrastructure
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Erythrocytes / metabolism
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Erythrocytes / parasitology*
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Evolution, Molecular
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Genes, Protozoan
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Genome, Protozoan*
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Humans
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Ligands
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Malaria Vaccines
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Merozoite Surface Protein 1 / chemistry
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Merozoite Surface Protein 1 / metabolism
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Multigene Family
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Plasmodium / pathogenicity
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Plasmodium / physiology
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Plasmodium falciparum / genetics*
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Plasmodium falciparum / pathogenicity*
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Plasmodium falciparum / physiology
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Plasmodium falciparum / ultrastructure
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Protein Structure, Tertiary
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Protozoan Proteins / chemistry
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Protozoan Proteins / metabolism*
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Receptors, Cell Surface / metabolism*
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Tight Junctions / ultrastructure
Substances
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Ligands
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Malaria Vaccines
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Merozoite Surface Protein 1
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Protozoan Proteins
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Receptors, Cell Surface