The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

Stephan Ludwig; Xiuyan Wang; Christina Ehrhardt; Hongyong Zheng; Nicola Donelan; Oliver Planz; Stephan Pleschka; Adolfo García-Sastre; Gudrun Heins; Thorsten Wolff

doi:10.1128/jvi.76.21.11166-11171.2002

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

J Virol. 2002 Nov;76(21):11166-71. doi: 10.1128/jvi.76.21.11166-11171.2002.

Authors

Stephan Ludwig¹, Xiuyan Wang, Christina Ehrhardt, Hongyong Zheng, Nicola Donelan, Oliver Planz, Stephan Pleschka, Adolfo García-Sastre, Gudrun Heins, Thorsten Wolff

Affiliation

¹ Institut für Molekulare Medizin, Heinrich Heine-Universität, 40225 Düsseldorf, Germany.

Abstract

The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Chlorocebus aethiops
Dogs
Down-Regulation
Enzyme Activation
Gene Expression Regulation
Influenza A virus / genetics
Influenza A virus / metabolism*
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases / metabolism*
RNA, Double-Stranded
Transcription Factor AP-1 / metabolism*
Up-Regulation
Vero Cells
Viral Nonstructural Proteins / genetics
Viral Nonstructural Proteins / metabolism*

Substances

INS1 protein, influenza virus
RNA, Double-Stranded
Transcription Factor AP-1
Viral Nonstructural Proteins
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases