Multiple sclerosis-associated retrovirus and MS prognosis: an observational study

S Sotgiu; C Serra; G Mameli; M Pugliatti; G Rosati; G Arru; A Dolei

doi:10.1212/wnl.59.7.1071

Multiple sclerosis-associated retrovirus and MS prognosis: an observational study

Neurology. 2002 Oct 8;59(7):1071-3. doi: 10.1212/wnl.59.7.1071.

Authors

S Sotgiu¹, C Serra, G Mameli, M Pugliatti, G Rosati, G Arru, A Dolei

Affiliation

¹ Institute of Clinical Neurology, University of Sassari, Italy. [email protected]

PMID: 12370465
DOI: 10.1212/wnl.59.7.1071

Abstract

MS-associated retrovirus (MSRV) in the CSF may have gliotoxic properties and could be associated with a more disabling MS. The authors tested this hypothesis in 15 untreated patients with MS: 6 MSRV- and 9 MSRV+ at the time of CSF withdrawal. After a 3-year mean follow-up, MSRV- patients showed a stable MS course, whereas MSRV+ patients had a progressive course (p = 0.01).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Chi-Square Distribution
Female
Follow-Up Studies
Humans
Male
Multiple Sclerosis / cerebrospinal fluid
Multiple Sclerosis / diagnosis
Multiple Sclerosis / virology*
Prognosis
Retroviridae / isolation & purification*
Retroviridae Infections / cerebrospinal fluid
Retroviridae Infections / diagnosis
Retroviridae Infections / virology*