Abstract
We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with the strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Amino Acid Sequence
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CD8-Positive T-Lymphocytes / immunology*
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Female
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Gene Products, nef / chemistry
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Gene Products, nef / genetics
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HIV Infections / immunology*
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HIV Infections / virology
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HIV Long Terminal Repeat / genetics
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HIV Long-Term Survivors*
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HIV-1 / genetics
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HIV-1 / immunology*
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HIV-1 / pathogenicity
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Humans
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Infant, Newborn
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Infant, Premature, Diseases / immunology*
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Molecular Sequence Data
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nef Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, nef
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nef Gene Products, Human Immunodeficiency Virus