Abstract
The aim of the present study was to evaluate the effects of ionic (ioxaglate) and non-ionic (iopromide) contrast media on haemostatic parameters ex vivo. In 40 patients undergoing coronary angiography, platelet function (platelet reactivity and serotonin concentration) and coagulation markers [thrombin-antithrombin III complexes, prothrombin fragments (F1+2) and the D-dimers] were measured. The use of an ionic X-ray contrast agent (XCA) (ioxaglate) in diagnostic cardiac catheterisation angiography is associated with lower thrombin generation and lower activation of the platelet system than when a non-ionic XCA is employed (iopromide). The results thus confirm the results of various in vitro studies and animal investigations.
Copyright 2002 S. Karger AG, Basel
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
MeSH terms
-
Aged
-
Antithrombin III
-
Blood Platelets / drug effects*
-
Blood Platelets / metabolism
-
Cardiac Catheterization* / adverse effects
-
Contrast Media / chemistry
-
Contrast Media / pharmacology*
-
Coronary Angiography*
-
Coronary Disease / blood
-
Coronary Disease / diagnostic imaging
-
Endothelium, Vascular / injuries
-
Female
-
Fibrin Fibrinogen Degradation Products / analysis
-
Hemostasis / drug effects*
-
Humans
-
Iohexol / analogs & derivatives*
-
Iohexol / pharmacology*
-
Ioxaglic Acid / pharmacology*
-
Male
-
Middle Aged
-
Peptide Fragments / blood
-
Peptide Hydrolases / blood
-
Platelet Activation / drug effects
-
Platelet Count
-
Prospective Studies
-
Prothrombin
-
Serotonin / metabolism
Substances
-
Contrast Media
-
Fibrin Fibrinogen Degradation Products
-
Peptide Fragments
-
antithrombin III-protease complex
-
fibrin fragment D
-
prothrombin fragment 1.2
-
Serotonin
-
Iohexol
-
iopromide
-
Antithrombin III
-
Prothrombin
-
Peptide Hydrolases
-
Ioxaglic Acid