Functionalized pyridylboronic acids and their Suzuki cross-coupling reactions to yield novel heteroarylpyridines

Paul R Parry; Changsheng Wang; Andrei S Batsanov; Martin R Bryce; Brian Tarbit

doi:10.1021/jo020388b

Functionalized pyridylboronic acids and their Suzuki cross-coupling reactions to yield novel heteroarylpyridines

J Org Chem. 2002 Oct 18;67(21):7541-3. doi: 10.1021/jo020388b.

Authors

Paul R Parry¹, Changsheng Wang, Andrei S Batsanov, Martin R Bryce, Brian Tarbit

Affiliation

¹ Department of Chemistry, University of Durham, Durham, DH1 3LE England.

PMID: 12375993
DOI: 10.1021/jo020388b

Abstract

2-Bromo-5-pyridylboronic acid 2a, 2-chloro-5-pyridylboronic acid 2b, 2-methoxy-5-pyridylboronic acid 2c, and 5-chloro-2-methoxy-4-pyridylboronic acid 4 have been synthesized and shown to undergo palladium-catalyzed cross-coupling reactions with heteroaryl bromides to yield novel heteroarylpyridine derivatives. The X-ray crystal structures of 2a and 2b have been obtained.