We describe an outbreak of Aujeszky's disease (AD) in a wild boar (Sus scrofa) population from central Spain. Mortality was estimated to be at least 14% (14/100) in juveniles and 7.5% (3/40) in adults. Most of the affected animals (12/17) were between 4 and 8 months of age. Gross lesions mainly consisted of enlarged and congestive tonsils and lymph nodes, petechial hemorrhages on the small intestine, and engorged blood vessels in the brain and meninges. Histopathology revealed mild nonsuppurative meningoencephalitis. Positivity to the fluorescent antibody test was found in tissues from the affected animals. Seroprevalence of antibodies to AD virus (ADV) was 56% (9/16). To our knowledge, this is the first description of clinical cases in a wild suid population.