In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study

Amanda J Leach; Peter S Morris; Heidi Smith-Vaughan; John D Mathews

doi:10.1128/AAC.46.11.3648-3649.2002

In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study

Antimicrob Agents Chemother. 2002 Nov;46(11):3648-9. doi: 10.1128/AAC.46.11.3648-3649.2002.

Authors

Amanda J Leach¹, Peter S Morris, Heidi Smith-Vaughan, John D Mathews

Affiliation

¹ Menzies School of Health Research, Darwin, Northern Territory, Australia. [email protected]

Abstract

This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics.

Publication types

Case Reports

MeSH terms

Bronchitis / microbiology
Chronic Disease
Drug Resistance, Multiple, Bacterial
Humans
Infant
Male
Microbial Sensitivity Tests
Nasopharynx / microbiology*
Penicillin Resistance*
Penicillins / pharmacology*
Penicillins / therapeutic use
Pneumonia, Pneumococcal / drug therapy
Pneumonia, Pneumococcal / microbiology*
Recurrence
Serotyping
Streptococcus pneumoniae / classification
Streptococcus pneumoniae / drug effects*
Time Factors

Substances

Penicillins