Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains

Int J Antimicrob Agents. 2002 Sep;20(3):227-9. doi: 10.1016/s0924-8579(02)00159-0.

Abstract

Eleven analogues of nifedipine (NP) showed synergistic interactions with ampicillin (Ap) and erythromycin (Er) on Escherichia coli K12LE140/F'lac. The antibacterial effect of Ap was enhanced by most analogues but compound (G9) and (+/-)-verapamil (VP) were antagonistic. Two of the 11 compounds (G7, G8) were synergistic with Er and four were additive. With a sensitive clinical isolate of E. coli Gy-1/Ap(sens)Er(res), compound G1 antagonized the antibacterial effect of Ap and a synergistic effect was found in the combination of Er with G4, G5, G6 or G7. None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/Ap(res)Er(res).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ampicillin / antagonists & inhibitors
  • Ampicillin / pharmacology*
  • Anti-Bacterial Agents / pharmacology
  • Dihydropyridines / chemistry
  • Dihydropyridines / pharmacology*
  • Drug Interactions
  • Drug Resistance, Bacterial
  • Erythromycin / pharmacology*
  • Escherichia coli / classification*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nifedipine / analogs & derivatives*
  • Nifedipine / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Dihydropyridines
  • Erythromycin
  • Ampicillin
  • Nifedipine