Abstract
Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3',4'-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / pharmacology
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Cell Division / drug effects
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Dose-Response Relationship, Drug
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Drug Resistance, Multiple*
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Drug Synergism
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Humans
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Structure-Activity Relationship
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Sucrose / analogs & derivatives*
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Sucrose / chemistry
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Sucrose / pharmacology*
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Tumor Cells, Cultured
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Verapamil / pharmacology