We present a case of non-anastomotic biliary strictures, mainly and initially localized in the right hemiliver and subsequently extending to the IV segment, in a 65-year-old male who had undergone liver transplantation because of hepatitis B virus-related cirrhosis. After the failure of endoscopic and percutaneous interventions, the patient was successfully treated by means of extended right hepatectomy up to 70% of graft volume. The surgical technique of liver graft resection is discussed. The authors recommend hepatic resection as a graft-saving option in selected patients affected by non-anastomotic biliary strictures in order to rescue the graft and avoid retransplantation.