Immediate early gene expression in the visual cortex of normal and dark reared cats: differences between fos and egr-1

Brain Res Mol Brain Res. 2002 Sep 30;105(1-2):157-60. doi: 10.1016/s0169-328x(02)00405-9.

Abstract

Northern blotting indicated that the level of induced fos was higher in normal than dark reared cat visual cortex (VC) at 5 weeks of age, comparable at 10 weeks, and higher in dark reared than normal cat visual cortex at 20 weeks. Fos egr-1, induction was higher in dark reared visual cortex at all ages. Thus, dark rearing has similar effects on fos, but not egr-1, expression as it has on physiological neuronal plasticity during the VC critical period.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cats
  • Cell Differentiation / genetics*
  • DNA-Binding Proteins / genetics
  • Dark Adaptation / genetics*
  • Gene Expression Regulation, Developmental / genetics*
  • Genes, Immediate-Early / genetics*
  • Neuronal Plasticity / genetics*
  • Neurons / metabolism
  • Proto-Oncogene Proteins c-fos / genetics
  • RNA, Messenger / metabolism
  • Sensory Deprivation / physiology*
  • Transcription Factors / genetics
  • Visual Cortex / growth & development*
  • Visual Cortex / metabolism

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins c-fos
  • RNA, Messenger
  • Transcription Factors