Abstract
Five patients with inoperable advanced gastric cancer were treated with combination chemotherapy of TS-1 and cisplatin (CDDP). TS-1 of 80-120 mg/body/day was orally administered for 3 weeks followed by 2 drug-free weeks, and 60 mg/m2/day of CDDP was venally administered on Day 8. It was possible to evaluate all 5 patients for response and toxicity. Only low grade toxicities (Grade 1 or 2) of leukocytopenia, neutrocytopenia, anemia, nausea, diarrhea and stomatitis were seen. Four of 5 patients achieved a partial response, for a response rate of 80.0%. Stomach, liver, lymph node and peritoneal tumors responded to TS-1/CDDP. TS-1/CDDP therapy produces a high response in cases of gastric cancer, and it is useful as a neoadjuvant chemotherapy.
MeSH terms
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Aged
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Anemia / chemically induced
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cisplatin / administration & dosage
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Cisplatin / adverse effects
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Drug Administration Schedule
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Drug Combinations
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Female
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Humans
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Leukopenia / chemically induced
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Lymphatic Metastasis
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Male
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Middle Aged
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Nausea / chemically induced
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Neoadjuvant Therapy
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Oxonic Acid / administration & dosage
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Oxonic Acid / adverse effects
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Preoperative Care
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Pyridines / administration & dosage
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Pyridines / adverse effects
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Tegafur / administration & dosage
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Tegafur / adverse effects
Substances
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Drug Combinations
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Pyridines
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S 1 (combination)
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Tegafur
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Oxonic Acid
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Cisplatin