Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia

Giorgina Specchia; Francesco Albano; Luisa Anelli; Clelia Tiziana Storlazzi; Giuseppe Cimino; Arcangelo Liso; Antonella Zagaria; Vincenzo Liso; Mariano Rocchi

doi:10.1046/j.1365-2141.2002.03846.x

Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia

Br J Haematol. 2002 Nov;119(2):488-91. doi: 10.1046/j.1365-2141.2002.03846.x.

Authors

Giorgina Specchia¹, Francesco Albano, Luisa Anelli, Clelia Tiziana Storlazzi, Giuseppe Cimino, Arcangelo Liso, Antonella Zagaria, Vincenzo Liso, Mariano Rocchi

Affiliation

¹ Department of Haematology, University of Bari, Italy. [email protected]

PMID: 12406090
DOI: 10.1046/j.1365-2141.2002.03846.x

Abstract

We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosome Mapping
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 19*
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Translocation, Genetic*