Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections

Steffen Borrmann; Nicole Szlezák; Ronald K Binder; Michel A Missinou; Bertrand Lell; Peter G Kremsner

doi:10.1093/jac/dkf200

Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections

J Antimicrob Chemother. 2002 Nov;50(5):751-4. doi: 10.1093/jac/dkf200.

Authors

Steffen Borrmann¹, Nicole Szlezák, Ronald K Binder, Michel A Missinou, Bertrand Lell, Peter G Kremsner

Affiliation

¹ Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B P 118, Gabon. [email protected]

PMID: 12407136
DOI: 10.1093/jac/dkf200

Abstract

This study evaluated the efficacy and safety of a 3-day course of artesunate (4 mg/kg/day) for asymptomatic Plasmodium malariae infections. The parasitological cure rates on days 7 and 56 in the group treated with artesunate were 100% and 83%, respectively, compared with no cure in the placebo group (P < 0.0001).

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Adolescent
Animals
Artemisinins / pharmacology
Artemisinins / therapeutic use*
Artesunate
Child
Double-Blind Method
Female
Humans
Malaria / blood
Malaria / drug therapy*
Male
Plasmodium malariae* / drug effects
Sesquiterpenes / pharmacology
Sesquiterpenes / therapeutic use*

Substances

Artemisinins
Sesquiterpenes
Artesunate