1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis

J Med Chem. 2002 Nov 7;45(23):4947-9. doi: 10.1021/jm020070b.

Abstract

Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.

MeSH terms

  • Administration, Oral
  • Animals
  • Apoptosis / drug effects*
  • Cells, Cultured
  • Enzyme Activators / pharmacology*
  • Indazoles / chemical synthesis*
  • Indazoles / chemistry
  • Indazoles / pharmacology
  • Mice
  • Muscle Cells / drug effects
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects
  • Nitric Oxide Donors / pharmacology*
  • Nitroprusside / pharmacology*
  • Rats
  • Sepsis / mortality

Substances

  • 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole
  • 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole
  • Enzyme Activators
  • Indazoles
  • Nitric Oxide Donors
  • 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
  • Nitroprusside