Abstract
A microdilution test measuring imipenem MICs in the presence or absence of a mixture of EDTA plus 1,10-phenanthroline was developed and tested on 190 Pseudomonas aeruginosa isolates, including 18 VIM- and 4 IMP-type metallo-beta-lactamase (MBL) producers. The chelator mixture reduced by fourfold or more the imipenem MICs for MBL producers, while a lower effect or no effect was usually observed with MBL nonproducers.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Chelating Agents
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Edetic Acid
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Humans
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Imipenem / pharmacology*
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Microbial Sensitivity Tests
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Phenanthrolines
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / enzymology*
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Chelating Agents
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Phenanthrolines
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Imipenem
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Edetic Acid
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beta-Lactamases
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1,10-phenanthroline