Abstract
Discovery of new chemical leads of inhibitors for TNF-alpha production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-alpha expression in the liver and spleen of mice. Structure-activity relationships (SARs) are also discussed and full details including the chemistry are reported.
MeSH terms
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Animals
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Female
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Indans / administration & dosage
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Indans / chemical synthesis*
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Indans / pharmacology
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Inhibitory Concentration 50
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Injections, Intravenous
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Lipopolysaccharides / pharmacology
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Liver / chemistry
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Male
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Mice
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Mice, Inbred BALB C
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Organophosphorus Compounds / administration & dosage
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Organophosphorus Compounds / chemical synthesis
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Organophosphorus Compounds / pharmacology
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Spleen / chemistry
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / analysis
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Indans
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Lipopolysaccharides
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Organophosphorus Compounds
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Tumor Necrosis Factor-alpha