[D-Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism

Methods Mol Med. 2003:74:299-307. doi: 10.1385/1-59259-323-2:299.
No abstract available

MeSH terms

  • Apoptosis / drug effects*
  • Carcinoma, Small Cell / enzymology*
  • Carcinoma, Small Cell / pathology
  • Cell Division / drug effects
  • Enzyme Activation
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • Lung Neoplasms / enzymology*
  • Lung Neoplasms / pathology
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinases / metabolism*
  • Peptide Fragments / pharmacology*
  • Precipitin Tests
  • Substance P / analogs & derivatives*
  • Substance P / antagonists & inhibitors*
  • Substance P / pharmacology*
  • Time Factors
  • Tumor Cells, Cultured

Substances

  • Peptide Fragments
  • substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)-
  • Substance P
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinases