Abstract
A new fluorescent ligand for adenosine receptors, obtained by the insertion of a dansylamino-moiety with a linear hexyl spacer in the N4 position of a 1,8-naphthyridine adenosine receptor ligand, proved to possess a high affinity and selectivity for the A1 receptor subtype.
MeSH terms
-
Animals
-
Binding, Competitive
-
Cattle
-
Cell Membrane / metabolism
-
Cerebral Cortex / metabolism
-
Dansyl Compounds / chemical synthesis
-
Dansyl Compounds / chemistry*
-
Fluorescent Dyes / chemical synthesis
-
Fluorescent Dyes / chemistry*
-
Fluorescent Dyes / metabolism
-
Humans
-
Kinetics
-
Naphthyridines / chemical synthesis
-
Naphthyridines / chemistry*
-
Naphthyridines / metabolism
-
Radioligand Assay
-
Receptors, Purinergic P1 / chemistry
-
Receptors, Purinergic P1 / metabolism*
Substances
-
4-(6-(dansylamino)hexylamino)-7-methyl-2-phenyl-1,8-naphthyridine
-
Dansyl Compounds
-
Fluorescent Dyes
-
Naphthyridines
-
Receptors, Purinergic P1