Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

Development. 2002 Dec;129(24):5719-30. doi: 10.1242/dev.00168.

Abstract

During animal development, organ size is determined primarily by the amount of cell proliferation, which must be tightly regulated to ensure the generation of properly proportioned organs. However, little is known about the molecular pathways that direct cells to stop proliferating when an organ has attained its proper size. We have identified mutations in a novel gene, shar-pei, that is required for proper termination of cell proliferation during Drosophila imaginal disc development. Clones of shar-pei mutant cells in imaginal discs produce enlarged tissues containing more cells of normal size. We show that this phenotype is the result of both increased cell proliferation and reduced apoptosis. Hence, shar-pei restricts cell proliferation and promotes apoptosis. By contrast, shar-pei is not required for cell differentiation and pattern formation of adult tissue. Shar-pei is also not required for cell cycle exit during terminal differentiation, indicating that the mechanisms directing cell proliferation arrest during organ growth are distinct from those directing cell cycle exit during terminal differentiation. shar-pei encodes a WW-domain-containing protein that has homologs in worms, mice and humans, suggesting that mechanisms of organ growth control are evolutionarily conserved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • Cell Cycle Proteins / biosynthesis
  • Cell Cycle Proteins / physiology*
  • Cell Differentiation
  • Cell Division
  • Cell Separation
  • Chromosome Mapping
  • Cloning, Molecular
  • Conserved Sequence
  • Cyclin E / biosynthesis
  • Drosophila / embryology*
  • Drosophila Proteins / biosynthesis
  • Drosophila Proteins / physiology*
  • Epithelium / embryology
  • Flow Cytometry
  • Gene Expression Regulation, Developmental*
  • Green Fluorescent Proteins
  • Head / embryology
  • Immunohistochemistry
  • In Situ Hybridization
  • Luminescent Proteins / metabolism
  • Meiosis
  • Microscopy, Electron
  • Microscopy, Electron, Scanning
  • Models, Genetic
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Photoreceptor Cells / metabolism
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid
  • Thorax / embryology
  • Up-Regulation
  • rho GTP-Binding Proteins

Substances

  • Cell Cycle Proteins
  • Cyclin E
  • Drosophila Proteins
  • Luminescent Proteins
  • sav protein, Drosophila
  • Green Fluorescent Proteins
  • rho GTP-Binding Proteins