Abstract
A 57-year-old woman underwent liver transplantation and developed osteomyelitis in the femur attributable to Aspergillus fumigatus. The patient was treated successfully with amphotericin B and 5-fluorocytosine for 30 days, and then switched to itraconazole for 12 months. Plasma (1->3)-beta-D-glucan levels decreased significantly after the chemotherapy. Early diagnosis by (1->3)-beta-D-glucan measurement and extended treatment with itraconazole can improve the prognosis of invasive Aspergillus infection.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / therapeutic use
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Aspergillosis* / drug therapy
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Aspergillus fumigatus*
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Female
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Femur / microbiology
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Femur / pathology
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Humans
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Itraconazole / therapeutic use
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Liver Transplantation / adverse effects*
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Magnetic Resonance Imaging
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Middle Aged
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Osteomyelitis / blood
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Osteomyelitis / diagnosis
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Osteomyelitis / microbiology*
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Proteoglycans / blood
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Receptors, Transforming Growth Factor beta / blood
Substances
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Antifungal Agents
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Proteoglycans
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Receptors, Transforming Growth Factor beta
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betaglycan
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Itraconazole