Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats

Neurosci Lett. 2002 Nov 29;333(3):179-82. doi: 10.1016/s0304-3940(02)01101-1.

Abstract

To further investigate the efficacy of 5-HT(1A) receptor agonism on functional and histological outcome in traumatically-brain injured (TBI) rats, a single intraperitoneal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.1, 0.5, or 1.0 mg/kg) or vehicle was given 15 min after controlled cortical impact or sham injury. Function was assessed by established motor and cognitive tests on post-operative days 1-5 and 14-18, respectively. Cortical lesion volume and hippocampal CA(1)/CA(3) cell survival were quantified at 4 weeks. The administration of 8-OH-DPAT (0.5 mg/kg) attenuated spatial acquisition deficits and reduced hippocampal CA(3) cell loss vs. vehicle (P < 0.05). These data augment published reports that 5-HT(1A) receptor agonists confer neuroprotective effects after experimental TBI.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
  • 8-Hydroxy-2-(di-n-propylamino)tetralin / therapeutic use*
  • Animals
  • Brain Injuries / complications
  • Brain Injuries / prevention & control*
  • Cognition / drug effects
  • Cognition / physiology*
  • Cognition Disorders / prevention & control*
  • Dose-Response Relationship, Drug
  • Hippocampus / cytology
  • Hippocampus / drug effects
  • Hippocampus / pathology
  • Male
  • Maze Learning / drug effects
  • Maze Learning / physiology
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Random Allocation
  • Reaction Time
  • Receptors, Serotonin / physiology*
  • Receptors, Serotonin, 5-HT1
  • Serotonin Receptor Agonists / pharmacology
  • Serotonin Receptor Agonists / therapeutic use*
  • Time Factors

Substances

  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Receptor Agonists
  • 8-Hydroxy-2-(di-n-propylamino)tetralin