Abstract
This preliminary study investigated the potential role of staphylococcal superantigens in the pathogenesis of canine pyoderma. The staphylococcal enterotoxins A (SEA), SEB, SEC and SED, and the toxic shock syndrome toxin-1 (TSST-1) were assayed in isolates from skins of dogs with pyoderma. Culture supernatants from 25 of 96 isolates were positive for multiple superantigens, with SEA and SEC being the most frequently detected. In in vitro stimulation of canine peripheral blood mononuclear cells and quantitative flow cytometry revealed that low concentrations of SEA and SEB were potent stimulators of blastogenesis of T cells.
MeSH terms
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Animals
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Bacterial Toxins*
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Cell Division / immunology
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Dog Diseases / immunology
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Dog Diseases / microbiology*
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Dogs
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Enterotoxins / immunology
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Enterotoxins / metabolism*
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Flow Cytometry / veterinary
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Latex Fixation Tests / veterinary
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Leukocytes, Mononuclear / cytology
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Pyoderma / immunology
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Pyoderma / microbiology
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Pyoderma / veterinary*
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Staphylococcal Skin Infections / immunology
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Staphylococcal Skin Infections / microbiology
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Staphylococcal Skin Infections / veterinary*
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Staphylococcus / immunology
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Staphylococcus / isolation & purification*
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Staphylococcus / metabolism
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Superantigens / biosynthesis
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Superantigens / immunology*
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Virulence
Substances
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Bacterial Toxins
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Enterotoxins
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Superantigens
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enterotoxin F, Staphylococcal