A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3515-8. doi: 10.1016/s0960-894x(02)00822-3.

Abstract

The selective synthesis of 1,2-cis-hexofuranosyl 1-phosphates was readily accomplished according to a procedure based on the 'Remote Activation Concept'. This approach required (i) the preparation of suitable 1,2-trans-hexofuranosyl donors, so that new heterocyclic thiofuranosides were designed and synthesized, (ii) the stereocontrolled phosphorylation of the corresponding unprotected donors and (iii) the simple and fast purification of the resulting anomeric phosphates. This approach showed to be equally efficient in the galactose, glucose and mannose series.

MeSH terms

  • Galactosephosphates / chemical synthesis
  • Glucosephosphates / chemical synthesis
  • Glycosides / chemical synthesis
  • Mannosephosphates / chemical synthesis
  • Phosphorylation
  • Stereoisomerism
  • Sugar Phosphates / chemical synthesis*
  • Thioglycosides / chemistry

Substances

  • Galactosephosphates
  • Glucosephosphates
  • Glycosides
  • Mannosephosphates
  • Sugar Phosphates
  • Thioglycosides
  • galactose-1-phosphate
  • mannose 1-phosphate
  • glucose-1-phosphate