Abstract
The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects*
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Cell Nucleus / drug effects
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Cell Nucleus / ultrastructure
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Chromatin / drug effects
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Chromatin / ultrastructure
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Chromatography, High Pressure Liquid
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Colonic Neoplasms / pathology*
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DNA, Neoplasm / drug effects
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Flour / analysis*
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Humans
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Sphingosine / analogs & derivatives*
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Sphingosine / pharmacology
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Triticum / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Chromatin
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DNA, Neoplasm
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Sphingosine