Abstract
The aim of this study was to examine roles of p27, a cyclin-dependent kinase inhibitor, in cochleae of adult mice. Expression of p27 was found in cochlear supporting cells and spiral ganglion neurons of normal mice. Cisplatin treatment caused progressive degeneration of cochlear supporting cells and spiral ganglion neurons, and numbers of p27-positive cells in these cells decreased. This indicates a close relationship between p27 and cell death in cochleae. However, the relationships between decrease in number of p27-positive cells and that of survival cells differed according to type of cell. For Deiters' cells, there was apparent decrease in number of p27-positive cells, although no decrease in cell numbers. The present findings indicate that p27 plays roles in degeneration of cochleae according to cell type.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Death
-
Cisplatin / toxicity
-
Cochlea / metabolism*
-
Cochlea / pathology
-
Epithelial Cells / metabolism*
-
Epithelial Cells / pathology
-
Immunohistochemistry
-
Labyrinth Supporting Cells / drug effects
-
Labyrinth Supporting Cells / metabolism
-
Labyrinth Supporting Cells / pathology
-
Mice
-
Mice, Inbred C57BL
-
Microfilament Proteins / metabolism*
-
Muscle Proteins*
-
Nerve Degeneration / metabolism*
-
Nerve Degeneration / pathology
-
Neurons / metabolism*
-
Neurons / pathology
-
Organ of Corti / drug effects
-
Organ of Corti / metabolism
-
Organ of Corti / pathology
-
Spiral Ganglion / drug effects
-
Spiral Ganglion / metabolism
-
Spiral Ganglion / pathology
-
Time Factors
Substances
-
Microfilament Proteins
-
Muscle Proteins
-
Tagln protein, mouse
-
Cisplatin