Abstract
We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenocarcinoma / enzymology*
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Adenocarcinoma / genetics
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Adenocarcinoma / mortality
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DNA, Complementary / genetics
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Disease Progression
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Enzyme Induction
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Gastric Mucosa / enzymology
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic
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Group II Phospholipases A2
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Humans
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In Situ Hybridization
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Life Tables
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Oligonucleotide Array Sequence Analysis
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Phospholipases A / biosynthesis
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Phospholipases A / genetics
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Phospholipases A / physiology*
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Phospholipases A2
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Prognosis
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Reverse Transcriptase Polymerase Chain Reaction
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Stomach Neoplasms / enzymology*
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Stomach Neoplasms / genetics
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Stomach Neoplasms / mortality
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Survival Analysis
Substances
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DNA, Complementary
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Neoplasm Proteins
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Phospholipases A
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Group II Phospholipases A2
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PLA2G2A protein, human
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Phospholipases A2
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Pla2g2a protein, mouse