Abstract
The aim of our study was to evaluate the possible prognostic and predictive significance of the expression of P-glycoprotein, a transmembrane transport protein related to multidrug resistance, in previously untreated patients with FIGO stage III ovarian cancer; to compare the results of immunocytochemical analysis of tissue sections of tumors to the in vitro chemosensitivity to cytotoxic drug of fresh samples of the same tumors; and to evaluate survival in women who underwent the same surgical treatment and the same adjuvant chemotherapy.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / analysis
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis*
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Adenosine Triphosphate / analysis
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Adenosine Triphosphate / pharmacology
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Biomarkers / analysis
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Carcinoma / drug therapy*
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Carcinoma / genetics
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Carcinoma / pathology
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Drug Resistance, Multiple*
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Drug Screening Assays, Antitumor
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Epirubicin / administration & dosage
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Female
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Genes, MDR*
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Humans
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Immunohistochemistry
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Middle Aged
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / pathology
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Predictive Value of Tests
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Prognosis
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Survival
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Biomarkers
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Epirubicin
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Adenosine Triphosphate
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Cyclophosphamide
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Cisplatin