Sequential regimen for early post-surgical infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA), unresponsive to standard antibiotic therapy: a case report

J Chemother. 2002 Oct;14(5):526-9. doi: 10.1179/joc.2002.14.5.526.

Abstract

We describe a patient with early post-surgical infective endocarditis due to methicillin-resistant Staphylococcus aureus, who was unsuitable for surgical reintervention and who failed standard antistaphylococcal therapy, but was successfully cured with a sequential regimen including quinupristin/dalfopristin and linezolid.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / pharmacology*
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents / pharmacology*
  • Cardiovascular Surgical Procedures / adverse effects
  • Drug Administration Schedule
  • Drug Therapy, Combination / pharmacology*
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / etiology
  • Female
  • Humans
  • Linezolid
  • Methicillin Resistance
  • Mitral Valve Insufficiency / surgery
  • Oxazolidinones / pharmacology*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / etiology
  • Surgical Wound Infection / drug therapy*
  • Surgical Wound Infection / etiology
  • Virginiamycin / pharmacology*

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Virginiamycin
  • quinupristin-dalfopristin
  • Linezolid