Cell migration is essential in species ranging from bacteria to humans (for recent reviews, see Lauffenburger and Horwitz 1996; Mitchison and Cramer 1996; Montell 1999). In the amoebae Dictyostelium discoideum, cell migration is involved in chemotaxis toward food sources and in aggregation (for review, see Devreotes and Zigmond 1988; Parent and Devreotes 1999; Chung et al. 2001). In higher vertebrates, cell migration plays crucial roles in multiple physiological and pathological processes. During embryonic and neonatal development, cell migration is crucial in morphogenetic processes such as gastrulation, cardiogenesis, and the formation of the nervous system (for review, see Hatten and Mason 1990; Rakic 1990; Hatten and Heintz 1998; Bentivoglio and Mazzarello 1999). In adult animals, cell migration is required for leukocyte trafficking and inflammatory responses (for review, see McCutcheon 1946; Harris 1954; Devreotes and Zigmond 1988). In tumoriogenesis, tumor-induced angiogenesis and tumor metastasis both involve cell migration. Although it is well known that cell migration is necessary for all these processes, our understanding of mechanisms controlling cell migration is still limited. Here we briefly review the significance of neuronal migration and focus on recent studies on the directional guidance of neuronal migration, discussing the possibility that guidance mechanisms for neurons are conserved with those for other somatic cells.