Abstract
[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkanes*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / pathology
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Carbamates*
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Female
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Humans
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Lactones / chemical synthesis*
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Lactones / chemistry*
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Lactones / pharmacology*
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Macrolides*
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / pathology
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Pyrones
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Tumor Cells, Cultured
Substances
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Alkanes
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Antineoplastic Agents
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Carbamates
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Lactones
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Macrolides
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Pyrones
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dictyostatin
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discodermolide