Sequence of the HLA-B*1573 allele

Tissue Antigens. 2002 Oct;60(4):331-2. doi: 10.1034/j.1399-0039.2002.600408.x.

Abstract

We report here the sequence of an HLA B*15 allele, B*1573. Initially, a cord blood unit from the Umbilical Cord Bank of Barcelona was typed by sequence-specific oligonucleotide hybridization and revealed an unusual hybridization pattern. After the cloning, the sequence-based typing assigned two different alleles: B*07021, and a second allele identical to B*1558 in exons 2 and 3, except for a single nucleotide substitution in exon 3, which changed codon 140 from Phe to Leu (TTX-->TTA).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Base Sequence
  • Exons
  • Fetal Blood / immunology
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • HLA-B15 Antigen
  • Histocompatibility Testing
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Polymerase Chain Reaction
  • Sequence Alignment

Substances

  • HLA-B Antigens
  • HLA-B15 Antigen

Associated data

  • GENBANK/AJ459483