Tc 99m sestamibi imaging is used in nuclear oncology, cardiology, but its role in detecting lymphomas has not been widely investigated. During 1998-2001 at the Department of Nuclear medicine, Kaunas University Hospital 68 patients with lymphomas (50 patients with Hodgkins disease (HD), 18 with non-Hodgkins (NHL)) underwent Tc 99m MIBI whole-body imaging. Of the 47 lymphoma lesions showed abnormal MIBI uptake. The accuracy of MIBI scintigraphy in patients with Hodgkins disease was lower (78%) compared to that of patients with non-Hodgkins lymphomas (94%). However, this difference was not related to tumor type, but to lesion size. Tumor size was significantly (p = 0.01) higher in lesions NHL with increased MIBI uptake (3.9 +/- 2.5 cm) compared with those with no uptake (1.5 +/- 0.5 cm).